Endothelin induces potent microvascular constriction
نویسندگان
چکیده
منابع مشابه
Endothelin antagonists block α1-adrenergic constriction of coronary arterioles.
We have previously observed that intracoronary administration of the α1-adrenergic agonist phenylephrine (PE) over a period of minutes induced both an immediate and long-lasting (2 h) vasoconstriction of epicardial coronary arterioles. Because it is unlikely that α1-adrenergic constriction would persist for hours after removal of the agonist, this observation supports the view that another cons...
متن کاملEndothelin antagonists block a1-adrenergic constriction of coronary arterioles
DeFily, David V., Yasuhiro Nishikawa, and William M. Chilian. Endothelin antagonists block a1-adrenergic constriction of coronary arterioles . Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1028–H1034, 1999.—We have previously observed that intracoronary administration of the a1-adrenergic agonist phenylephrine (PE) over a period of minutes induced both an immediate and long-lasting (2 h) vaso...
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Endothelin is a potent vasoconstrictive peptide initially characterized as a product of endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the human central nervous system. RNA blot hybridization provided evidence of endothelin gene transcription in a variety of functional regions of the brain. In situ hybridization confirmed the wid...
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Cilostazol is a phosphodiesterase inhibitor that has been shown to inhibit platelet activation. Endothelin is known to be the most potent endogenous growth promoting and vasoactive peptide. In patients and animal models with stroke, the level of circulating endothelin increases and complicates the recovery progress contributed by vascular constriction (an immediate pathology) and vascular proli...
متن کاملCellular mechanisms mediating rat renal microvascular constriction by angiotensin II.
To assess cellular mechanisms mediating afferent (AA) and efferent arteriolar (EA) constriction by angiotensin II (AngII), experiments were performed using isolated perfused hydronephrotic kidneys. In the first series of studies, AngII (0.3 nM) constricted AAs and EAs by 29+/-3 (n = 8, P < 0.01) and 27+/-3% (n = 8, P < 0.01), respectively. Subsequent addition of nifedipine restored AA but not E...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1988
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1988.tb11731.x